Botham, P.A., M. Chamberlain, M.D. Barratt, R.D. Curren, D.J. Esdaile, J.R. Gardner, V.C. Gordon, B. Hildebrand, R.W. Lewis, M. Liebsch, P. Logemann, R. Osborne, M. Ponec, J.-F. Regnier, W. Steiling, A.P. Walker, and M. Balls. A Prevalidation Study on In Vitro Skin Corrosivity Testing. The Report and Recommendations of ECVAM Workshop. ATLA 1995. 23: 219-255.

This is the report of the sixth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM's main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine, or replace the use of laboratory animals. The workshop on "In Vitro Skin Corrosivity Testing was held in Angera, Italy on 12-14 January, 1994, under the chairmanship of Philip Botham. The workshop was concerned primarily with the discussion of a prevalidation study on alternative methods for skin corrosivity testing. The results and conclusions of the prevalidation study are given in this report, in addition to some specific recommendations which relate to future requirements in skin corrosivity testing. A follow-up meeting was held at ECVAM in February 1995 to finalise the workshop report, to review further test optimisation conducted since January 1994, and to discuss the design of a validation study on alternative methods for corrosivity testing, which is to be sponsored by ECVAM.