Harvell, J. D. and H. I. Maibach. Validation of In Vitro Skin Irritation Assays Using Human In Vivo Data. In Vitro Toxicol. 1992. 5(4): 235-239.

The following (article) reviews validation aspects of in vitro dermal toxicity assays using in vivo human data. Ways of improving the in vivo arm of the in vivo/in vitro comparison are suggested. Examples of more objective methods of assessing in vivo skin irritation are discussed. It is felt that by improving the nature of the in vivo database, the overall in vitro/in vivo relevance assessment may be enhanced.