Monteiro-Riviere, N. Use of the Isolated Perfused Skin Model in Dermatotoxicity. In Vitro Toxicol. 1992. 5(4): 219-233.

sodium hydroxide - 1310-73-2; hydrochloric acid - 7647-01-0; 2-chloro methyl sulfide - 542-81-4; chlorovinyl dichloroarsine - 541-25-3; paraquat - 4685-14-7

 The isolated perfused porcine skin flap (IPPSF) is an alternative animal model used to study percutaneous absorption, cutaneous toxicity, and to pharmacokinetically model xenobiotic disposition within the skin. One of the advantages of this model is that it is a viable skin preparation with an automatically intact and functional microcirculation. A unique advantage is that the extent of percutaneous absorption can be modelled simultaneously with the assessment of cutaneous toxicity. Morphological, biochemical, and physiological indicators of chemical irritation can be analyzed in the same preparation. These advantages will be illustrated by reviewing the use of the IPPSF in studying the cutaneous toxicity of sodium hydroxide, hydrochloric acid, paraquat, 2-chloroethyl methyl sulfide, chlorovinyl dichloroarsine, bis 2-chloroethyl sulfide, and the process of transdermal iontophoretic drug delivery. This overview will place the use of the IPPSF in the proper perspective on how it may be used in dermatotoxicology.