Stobbe, J. L., K. D. Drake and K. J. Maier. Comparison of Dermal Corrosion Values for Selected Industrial Chemicals Using Corrositex. The Toxicologist 1999. 48(1S): 77. Abstract # 359.

Skin irritation is the most frequently reported occupational hazard for those employees engaged in the use and transport of industrial chemicals. The rabbit test is the most common in vivo method used to evaluate dermal irritation and/or corrosion. Several in vitro test methods have been developed, with Corrositex being the first to gain approval by a regulatory agent (DOT). Several classes of industrial chemicals, 24 formulations, were tested using the Corrositex method and the results were compared to standard animals data for each of the formulations. Based on the results, Corrositex accurately predicted a corrosive endpoint in 8 of the 24 formulations, when compared to the animal data, and accurately predicted a non-corrosive endpoint for 1 of the 24 formulations. The Corrositex assay overpredicted a corrosive endpoint for 6 of the 24 formulations. In addition, corrosive classifications (DOT Packing Groups) were also evaluated. The Corrositex assay overpredicted the Packing Group classification for 12 of the 24 formulations tested and underpredicted 7 of the 24 formulations tested. The Corrositex assay did not adequately predict a corrosive endpoint Packing Group for the 24 formulations used in this study. This study was practical application of the Corrositex method, and the method appears to have failed for predicting the corrosive hazards of the chemicals classes included in this study.